Olusegun Olaoye
Department of Food Science and Technology, Michael Okpara University of Agriculture, Umudike, Abia State. ORCID. Philippa C. Ojimelukwe: 0000-0002-0263-0597, Nigeria
Publications
-
Research Article
Establishing the Anti-Hyperglycemic Potency of Ethanol Extract of Moringa Oleifera Leaf on albino rat: Focusing on Optimization of Biomarkers of Type 2 Diabetes
Author(s): Patrick Udofia*, Philippa C. Ojimelukwe, Anthony Ukom, Olusegun Olaoye and Mfonobong Ekanem
In this study, the antihyperglycemic activity of ethanol extract of the leaf of Moringa oleifera (MO) was investigated. It was aimed at ascertaining the efficacy of MO ethanolic extract as an antihyperglycemic agent. To achieve the aims, streptozotocin (STZ) induced type 2 diabetic rats were treated with iterative levels of the plant ethanolic extract (X1). The time of exposure (X2) of the rats to the extract and time of storage of the leaf sample before extraction (X3) were monitored. Handling and the treatment of the rats followed strict adherence to the guidelines of the Committee for the Purpose of Control and Supervision of Experiments on Animals. The biomarkers of type 2 diabetes in the rats were esti- mated using standard methods. Optimization analysis on the data revealed that 100% of the plant extract would require 41.84 days of exposure of the rats to the plant extract to re.. Read More»