The Cellular Expression Dynamics of Endogenous Gp70 TAA Antigens in Cancer Cells and Their Biomarkers and Immunopotential for Clinical Relevance of Drug Combinations

Abstract

K.Ramalingam*, S.Paulraj, P.Karnan and A.Anbarasu

Cancer cells do not want to die. After the transformation of normal cells into malignant cancer cells they absorb more glucose from outside than the normal cells. With this induction more glycoproteins are synthesized. This glycoprotein becomes specific membrane antigens which are also shed into systemic circulation. These become the bio makers for cancer diagnosis. This is one of the reasons to regulate sugar intake by the cancer patients. Both oncogenic viruses and chemical carcinogens like methyl- cholanthrene can induce malignancy in normal cells. MST cells line is a virus induced cancer cell line. MST displays on its surface viral antigens, p30 and gp70 mainly. These antigens can induce in vitro the T cells, These T cells can be employed for successful cancer therapy. P30 on a cell membrane or insoluble p30 might be considered an effective immunogen. The cell cultured and procured growing T-cells are efficient effector cells to eliminate in vivo the established tumours either viral induced or chemically induced. Cancer cells survive even after radiation and chemotheraphy.

About 15% of residual cells remain alive at the primary site of tumour. These cells comprise the resistant cells, cancer stem cells, and cells which acquired the metastatic potential. In addition, the fibroblast cells in the outer boundary of the tumour also are transformed into malignant cells by the interaction and molecular talk between tumour cells and fibroblasts. So far the resistant capacity of metastatic cancer cells was construed as a trait due to multi-drug resistance gene. Recent investigations have unraveled the secret behind resistance, as due to over-expression of non-mutated sequences of cancer cells DNA and the epigenetic expression and coating of tumour associated antigens (TAA) over their cell surface. When secondary cancers are produced through metastasis the gp70 protein/antigens were attributed for the drug resistance as such gp70 cells among 30 percent of patients, show or document resistance by spitting out the chemo-drugs and even radiation therapy is of no use to them. (Prudent Proxies: K. Ramalingam 2018), The research domain in therapeutic cancer is now elaborated due to the contribution of non-mutated gene sequence towards the synthesis of tumour associated antigens (TAA) as shown in the case of Autoimmune SLE in murine model and in breast and colorectal cancers.

HTML PDF