International Journal of Cancer Research & Therapy(IJCRT)

Mediclone Research Centre, Mediclone Company, Chennai, India

Publications

• Research Article   
  The Cellular Expression Dynamics of Endogenous Gp70 TAA Antigens in Cancer Cells and Their Biomarkers and Immunopotential for Clinical Relevance of Drug Combinations
  Author(s): K.Ramalingam*, S.Paulraj, P.Karnan and A.Anbarasu
  
  Cancer cells do not want to die. After the transformation of normal cells into malignant cancer cells they absorb more glucose from outside than the normal cells. With this induction more glycoproteins are synthesized. This glycoprotein becomes specific membrane antigens which are also shed into systemic circulation. These become the bio makers for cancer diagnosis. This is one of the reasons to regulate sugar intake by the cancer patients. Both oncogenic viruses and chemical carcinogens like methyl- cholanthrene can induce malignancy in normal cells. MST cells line is a virus induced cancer cell line. MST displays on its surface viral antigens, p30 and gp70 mainly. These antigens can induce in vitro the T cells, These T cells can be employed for successful cancer therapy. P30 on a cell membrane or insoluble p30 might be considered an effective immunogen. The cell cultured and procure.. Read More»
  

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