Zhicheng Xiao
Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy, Australia
Publications
-
Research Article
The Collaborative Cross Mouse A Powerful Tool for Studying Complex Genetic Conditions of Neurogenesis and Brain Development
Author(s): Diji Kuriakose and Zhicheng Xiao*
Neurodegenerative disorders (NDD), like Alzheimer’s disease (AD), impose a large health and socio-economic burden. AD affected 50 million people worldwide in 2019, and was the fifth leading cause of death for people over 65 years old. Despite the high prevalences of NDDs, very little is known about their underlying mechanisms and causes. Commonly occurring comorbidities and symptoms – such as cognitive impairment – overlap, complicating differential diagnosis. Recent studies have also noted large differences between the diagnostic outcomes associated with different genetic causes. In humans, multiple genetic variants are associated with neurogenesis and NDDs. Most research on NDDs uses animal models that focus on a single mutation in a fixed genetic background, providing inadequate heterogeneity and power to map genes linked to complex disease conditions. Therefore, .. Read More»