Japanese Journal of Medical Science(JJMS)

Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

Publications

• Research Article   
  Efficacy of Intra-Articular Hyaluronic Acid Injections with INNORYOS 2.2% in Patients with Knee Osteoarthritis
  Author(s): Lola Hofweber, Wolfgang Kemmler, Jorg Nurnberger and Simon von Stengel
  
  Introduction: We determined the effectiveness and safety of INNORYOS 2.2% hyaluronic acid (HA) containing 1.5% of niacinamide on knee pain, stiffness and function in people with knee osteoarthritis (OA) compared with an established agent. Further study objectives were to monitor side effects during the study period. Methods: The 26-week prospective non-interventional open clinical trial tested on non-inferiority of INNORYOS 2.2% compared to an established HA product (Synvisc 0.8%, 2.0 ml). Briefly, 90 patients with knee OA (Kellgren-Lawrence grade I to III), 40-85 years old, were allocated randomly to the two groups. HA injections were carried out at baseline and after 1 and 2 weeks. Additional visits for data collection were made after 14 and 26 weeks. Changes in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), pain v.. Read More»
  

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