International Journal of Cancer Research & Therapy(IJCRT)
ISSN: 2476-2377 | DOI: 10.33140/IJCRT
Impact Factor: 1.3
Salwa Mohamed A. Elmahjob
Department of Medical Microbiology, Faculty of Medical, Laboratory Sciences, Shendi University, Shendi, Sudan
Publications
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Research Article
Micronucleus Frequency in Buccal Mucosal Cells Among Sudanese Asthmatic Patients Using Salbutamol Inhalers in Shendi City: A Comparative Cross-Sectional Study
Author(s): Abrar Ezaldin Mozamel Alawad, Abdalrhman Ali Alkhalifa Alhfyan, Mohammed Abdelgader Elsheikh, Ibrahim B. Elemam, Asma Al-Ameer M. Zeen, Zeinab A. Mohamed, Salwa Mohamed A. Elmahjob, Idris Mobarak I. Fadol, Ayat Mustafa O. Mohamed and Ghanem Mohammed Mahjaf
Background: Asthma is a chronic inflammatory disease commonly managed using salbutamol inhalers. Prolonged exposure to inhaled medications may induce genotoxic alterations, including micronucleus (MN) formation in buccal epithelial cells. Limited data exist regarding such effects among Sudanese asthmatic patients. Objective: To assess the frequency of micronuclei in buccal mucosa among asthmatic patients using salbutamol inhalers and compare the findings with healthy controls in Shendi City. Methods: A descriptive comparative cross-sectional study was conducted on 100 participants: 50 asthmatic patients using salbutamol inhalers and 50 age- and sex-matched healthy controls. Buccal smears were collected, fixed with 95% ethanol, and stained using the Papanicolaou technique. Micronuclei were examined microscopically, and data were analyzed using SPSS employing Chi-square and ANOVA tests... Read More»