Journal of Clinical, Medical, and Diagnostic Research(JCMDR)

Head of the Department of Fundamental Medical Disciplines, Institute of Medicine and Biology, Facult, Russian Federation

Publications

• Review Article   
  The Role of Polysaccharide Polymers in the Regulation of Angiogenesis and Atherogenic Inflammation in the Wall of Arterial Vessels. Analytical Review
  Author(s): Bolshakov Igor Nicolaevich*, Shindyakin Dmitry Vasilievich, Bahshyan Valentina Arturovna, Kirichenko Andrey Konstantinovich, Alyabyev Fedor Valerievich, Patlataya Nadezhda Nikolaevna and Arkhipkin Sergey Viktorovich
  
  Damage to peripheral arteries by the atherosclerotic process accounts for about 3% of the world's population, which puts this problem in the category of major social problems. Modified lipoproteins and cholesterol crystals are known to accumulate in the arterial intima and cause the formation of proatherogenic macrophages, foam cells, and inflammation. Defective efferocytosis of apoptotic foam cells leads to the formation of a necrotic core, a sign of failure to resolve inflammation. Resolution of inflammation is mediated by specialized pro-resorption lipid mediators, proteins and signaling gases. Improving the balance between pro- inflammatory and anti-inflammatory factors contributes to the reverse development of local atherogenesis. Active direct intervention in the reconstruction of the adventitial layer of the arterial wall using cholesterol-affinity polysaccharide hydrogels .. Read More»
  

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