Nanshan Zhong
State Key Laboratory of Respiratory Disease, Guangzhou Medical College, Guangzhou 510006, China
Publications
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Research Article
Structure/Epitope-Based Immunoinformatics Analysis of Structural Proteins of 2019 Novel Coronavirus
Author(s): Yuwei Li*, Liteng Yang*, Xizhuo Sun and Nanshan Zhong
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than ten million laboratory-confirmed human infections, including 20,000 deaths, posing a serious threat to human health. Currently, however, there is no specific antiviral treatment or vaccine. To identify immunodominant peptides for designing global peptide vaccine for combating the infections caused by 2019-nCoV, the structure and immunogenicity of 2019-nCoV structural protein were analyzed by bioinformatics tools. 33 B-cell epitopes and 39 T-cell epitopes were determined in four structural proteins via different immunoinformatic tools in which include spike protein (22 B-cell epitopes, 25 T-cell epitopes ), nucleocapsid protein (7 B-cell epitopes, 6 T-cell epitopes), membrane protein (2 B-cell epitopes, 7 T-cell epitopes), and envelope protein (2 B-cell epitopes, 1T-cell epitopes), respectively. The proportion.. Read More»