Mohammad A.K.Hasan
El kasr Al Aini, Cairo university, Egypt
Publications
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Research Article
Spironolactone Versus Eplerenone as Adjunctive Treatment in Patients with Heart Failure
Author(s): Mohammad A.K.Hasan* and Hossam Kandil
Background: The goals of treatment in patients with heart failure (HF) are to improve their clinical status, functional capacity, and quality of life, prevent hospital admission and reduce mortality. Aim of the work: This work aims to evaluate spironolactone versus eplerenone as an adjunctive therapy regarding tolerability in patients with HF (NYHA II to IV) already on anti-failure treatment with beta Blockers (BB) and/or ivabradine and their effect on major adverse cardiac events. Study design: 100 patients were recruited and randomized into 2 groups (n=50/group); group 1 received spironolactone 25mg/d that was titrated to 100mg/d if tolerated, while group 2 received eplerenone 25mg/d that was titrated to 50mg/d if tolerated. Follow up of: symptoms, signs, potassium level, BNP, renal functions, systolic function a.. Read More»