Journal of Traditional Medicine & Applications(JTMA)

Associate professor, Pharmacy Practice, ISF College of Pharmacy, India

Publications

• Research Article   
  SARS-CoV-2 mRNA Vaccines as Immunologic Adjuvants to Overcome Tumour Resistance to Immune Checkpoint Blockade
  Author(s): Sonu Kumar* and Khadga Raj Aran
  
  Immune checkpoint inhibitors (ICIs) have transformed oncologic care, yet their therapeutic efficacy remains limited in many patients due to tumour-intrinsic immune evasion and an immunosuppressive tumour microenvironment (TME) [1]. Recent evidence indicates that SARS-CoV-2 mRNA vaccines exert potent immunomodulatory effects beyond antiviral protection, acting as systemic primers of innate and adaptive immunity [2]. mRNA–lipid nanoparticle (LNP) formulations induce robust type I interferon signalling, dendritic-cell activation, and cytokine re-modelling, thereby reshaping the TME toward an immune-permissive state [3]. These immune-activating processes have been shown to enhance responsiveness to ICI therapy by promoting antitumor inflammation. In combined clinical and preclinical analyses, mRNA vaccination has been associated with increased tumour PD-L1 expression, expansion of e.. Read More»
  

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