Advances in Bioengineering and Biomedical Science Research(ABBSR)
ISSN: 2640-4133 | DOI: 10.33140/ABBSR
Impact Factor: 1.7
Hong Zheng
Department of pathology, Affiliated Hospital of Zunyi Medical University, China
Publications
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Research Article
Comprehensive Genetic Features of Serous Ovarian Tumor Patients Revealed PIK3CA Mutation and Chromosome Instability as Prognostic Biomarkers
Author(s): Jinjing Wang, Cunyi Gao, Junjun chen, Xue Li, Sisi Liu, Xue Wu, Yang Shao, Na Tan* and Hong Zheng*
Background: Ovarian cancer is the seventh most common cancer in women worldwide among which the most frequently occurred histological type is serous ovarian cancer (SOC). Since efficacious treatments for SOC have not advanced beyond platinum-based combination chemotherapy and more than 75% of high-grade SOC will relapse after first-line therapy, it is urgent to observe the genomic abnormalities and identify novel therapeutic targets and prognosis biomarkers. Methods: In order to comprehensively identify molecular features of serous ovarian cancer, we performed targeted sequencing with 425 cancer-related genes on four serous ovarian tumor (SOT) cohorts, classified as ovarian serous adenoma (OSA), ovarian serous borderline tumor (OSBT), low-grade serous cancer (LGSC) and high-grade serous cancer (HGSC). The association between genetic alterations.. Read More»