Toxicology and Applied Pharmacology Insights(TAPI)

Department of Pharmacology, KIET Group of Institutions, KIET School of Pharmacy, Delhi-NCR, Ghaziaba, India

Publications

• Research Article   
  Ameliorative Effect of Ferulic Acid against Cyclophosphamide Induced Behavioural and Biochemical Changes in Albino Mice
  Author(s): Vinay Kumar*, Himani Tyagi, Gauri Goyal, Priyanshi Varshney and Shardendu Kumar Mishra
  
  Background: Cyclophosphamide (CP) is a distinguished anticancer and immune subduing medicament but it has neurotoxicity as a limitation. Objective: The primary objective of this study was to describe the neuroprotective effects of ferulic acid in contradiction to cyclophosphamide-prompted neurotoxicity in the Swiss Albino mice. Methodology: Mice were alienated into five groups (n=7) and treated with FA for fourteen days and a single dose of CP was administered on the seventh day. Animals were imperilled to neurobehavioral tests such as Rotarod test, Tail suspension test, and Y-maze test. On day fifteenth, animals were forgone and brain was detached and used for biochemical analysis. Result: Cyclophosphamide administration likewise condensed the activity of antioxidant enzyme (GSH), and in.. Read More»
  

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