Gwang Hoon Kim
Department of Biological Sciences, Kongju National University, Republic of Korea
Publications
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Research Article
Fabrication and Characterization of Ascorbyl Propyl Hyaluronate for Skin Anti-Aging
Author(s): Ji Won Yu*, Hayoung Choi, Wonchoul Park, Jin-Su Kim and Gwang Hoon Kim
Background: Ascorbic acid (AA) is a powerful antioxidant that can help slow premature skin aging, improve the appearance of acne, wrinkles and dark spots, and against sun damage. Despite these advantages, the low oxidative stability and skin penetration rate of AA are major obstacles to commercial applications and require improvement. Methods: In this study, we developed ascorbyl propyl hyaluronate (APH), a hyaluronic acid conjugated with ascorbic acid, to overcome the disadvantages of AA. To confirm the characteristics of the developed APH, the thermal stability, skin penetration rate, and antioxidant capacity were evaluated, and the cell viability, cell proliferation, and skin-related cell regeneration efficacy were compared with the conventional AA. Results: We demonstrated that APH is improved thermal stability.. Read More»
