Current Research in Vaccines Vaccination(CRVV)

Center for Material Science, University of South Africa, UNISA Science Campus, South Africa

Publications

• Research Article   
  Protein Structural and Sequence Analysis of Human ACE2 Using Prediction and Modeling Bioinformatics Tools for Diagnostics Biomarkers and Drug Design Features: an Opinion Study Path
  Author(s): Ozurumba-Dwight Leo N*, Muller Claude P, Ndams Iliya S, Avan Dalton E, Enwere Okezie.O, Iyevhobu Kenneth O, Yinusa Titus, Ebenso Eno E and Obeagu Emmanuel I
  
  Angiotensin converting enzyme-2 receptor (ACE2) present on human cell membrane surfaces is a critical receptor for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) to bind onto and invade cells. Severe burden caused by the recent COVID-19 (coronavirus disease-2019) pandemic was of global public health and economic importance. ACE2 protein has multi-functional roles and its expression on cell membrane surfaces influences COVID-19 pathogenesis. Engagement of key bioinformatics tools that retrieves data from protein sequences can be compared with structure of ACE2 proteins from same individuals and patients of different clinical status for COVID-19 (for individuals that are non-infected, infected asymptomatic and symptomatic). This can either be from data obtained from disease states or from already deposited annotated data generated from past studies stored in protein databa.. Read More»
  

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