Cesar R Acosta
Franklin Cardiovascular Assoc., PA and Autonomic Dysfunction and POTS Center, Sicklerville, NJ, USA
Publications
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Review Article
Oral Vasoactive Medications: A Summary of Midodrine and Droxidopa as Applied to Orthostatic Dysfunction
Author(s): Nicholas L DePace, Aaron I Vinik, Cesar R Acosta, Howard J Eisen and Joe Colombo*
This is a summary of the uses and applications of two vasoactive drugs, Midodrine (ProAmatine) and Droxidopa (Northera), in the treatment of Orthostatic Dysfunction (OD) disorders, including Neurogenic Orthostatic Hypotension, Postural Orthostatic Tachycardia Syndrome (POTS). This summary based on 15 years of experience monitoring and serially treating over 4000 patients with OD from all around the world and supportive literature. OD caused by an abnormal (decrease) in α-adrenergic, or α-Sympathetic, activity when assuming a head-up posture (e.g., sitting or standing). OD symptoms typically include lightheadedness, brain-fog, neurocognitive loss, fatigue, sleep difficulties, anxiety, and Syncope. Decreasing α-adrenergic activity upon head-up postural change often underlies OD and may be relieved with vasoactive medications. Midodrine and Droxidopa are the only medica.. Read More»