Archives of Case Reports: Open Access(ACROA)

Independent Scholar, New Zealand

Publications

• Research Article   
  Reversible Exocrine Pancreatic Insufficiency in the Context of Autonomic Dysfunction: Extending the NOx (Knox) Hypothesis to the Gut-Brain-Pancreas Axis
  Author(s): Bruce H Knox*
  
  Background: Exocrine pancreatic insufficiency (EPI) is conventionally attributed to irreversible structural disease. Yet pancreatic exocrine output is regulated by a tightly integrated neurohormonal system involving vagal efferents, enteric circuits, gastrointestinal motility, and enteroendocrine signaling [1-4]. Disruption of autonomic regulation may impair exocrine secretion even when the pancreas is structurally intact. Objective: To extend the NOx (Knox) Hypothesis into pancreatic physiology, proposing that in selected cases EPI may represent a secondary, reversible manifestation of autonomic dysregulation rather than fixed glandular failure. Methods: Narrative integrative analysis combining longitudinal patient observation with contemporary literature on autonomic regulation, gut–brain–pancreas phy.. Read More»
  

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