Toxicology and Applied Pharmacology Insights(TAPI)

Tanzania Atomic Energy Commission (TAEC) P. O. Box 743 Arusha, Tanzania

Publications

• Research Article   
  Virtual Screening on Protein-Ligand Interactions: A Pharmacological Aspect of Zingiber Officinale for COVID-19 Remedy
  Author(s): Mikidadi S. Gurisha* and Atumain Makoba
  
  With the current pandemic of the novel coronavirus disease 2019(COVID-19) in hand, researchers around the world are dexterously working to find the best suitable drug candidates and to overcome vaccination-related challenges. In Tanzania, ginger (Zingiber officinale) has been taken as a traditional remedy for COVID-19 by processing it into a different drinks. Computer-aided drug discovery provides a promising attempt to allow scientists to develop new and target-specific drugs to fight any disease. Therefore, in this study, Virtual Screening was conducted on 113 phytochemicals derived from the Zingiber officinale herb to find lead molecules for SARS-CoV-2. A total of 10 phytochemicals qualified from PyRx Virtual Screening, out of which only 5, namely Gingerenone A, Jyperin, Meletin, Isorhamnetin and Shogaol demonstrated a substantial binding affinity with D614G SARS-CoV-2 protein, thi.. Read More»
  

  Abstract HTML PDF