Journal of Traditional Medicine & Applications(JTMA)
ISSN: 2833-1389 | DOI: 10.33140/JTMA
Impact Factor: 1.02
Atsamo Albert Donatien
Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, Cameroon
Publications
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Research Article
Combined Effect of Zingiber Officinale Rhizomes Extracts and Dried Fruits of Tetrapleura Tetraptera on Attenuated Monosodium-Iodoacetate-Induced Osteoarthritis Via its Analgesic, Anti-Inflammatory, Antioxidant and Anxiolytic Effects
Author(s): Djami Bejoutance Marcelle, Bilanda Danielle Claude, Atsamo Albert Donatien, Yousseu Nana William, Bomba Tatsinkou Francis Desire, Djuichou Nguemnang Stephanie Flore, Tcheutchoua Yannick Carlos, Bakouatche Jovanie Destin, Kwenthe Ernest Allah Hoki, Kana Miariam Flore, Mbiantcha Marius, Ateufack Gilbert* and Dzeufiet Djomeni Paul*
Ethnopharmacological Relevance: Zingiber officinale and Tetrapleura tetraptera are used by the population to treat many diseases. Aim of the Study: This study aimed to evaluate the therapeutic effects of the mixture of dried fruits of Tetrapleura tetraptera extract and the rhizomes of Zingiber officinal extract on osteoarthritis. Materials and Methods: Osteoarthritis was induced with monosodium-iodoacetate (50 μl, 100 mg/kg, i.a.). The extracts of the mixture of Zingiber officinale and Tetrapleura tetraptera (100, 200 mg/kg) was administered orally. Body mass, thermal hyperalgesia, paw volume, locomotion and anxiety states were assessed. The hematological, biochemical, anti- inflammatory, pro-inflammatory and oxidative stress parameters were measured. The microarchitecture of the knee joint was evaluated. .. Read More»