International Journal of Diabetes & Metabolic Disorders(IJDMD)
ISSN: 2475-5451 | DOI: 10.33140/IJDMD
Impact Factor: 1.23
Andrew Meal
Faculty of Medicine and Health Sciences, School of Health Sciences, University of Nottingham, Clifton Boulevard, Nottingham, United Kingdom
Publications
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Research Article
The Ability of Combination Sulfonylurea and Metformin in Reducing Morbidity and Mortality in Type 2 Diabetes
Author(s): Katie Fletcher, Andrew Meal and Gary G. Adams*
Background Literature: Type 2 diabetes is a health concern worldwide, and treatment with oral antidiabetic medicines presents a clinical challenge. This systematic review aims to assess the ability of combination sulfonylurea and metformin in reducing morbidity and mortality in type 2 diabetes. Methods A search of the databases NU Search, PubMed, Ovid, Embase, CINAHL and Medline was conducted by the author, using key search terms. 11 studies were included, 6 RCT’s, and 5 cohort studies with a combined number of 168,138 participants. Results Cardiovascular risk: Atherosclerotic Cardiovascular Disease (ASCVD) risk score DPP4i and metformin: -1.5 versus -1.1 for SU and metformin. Six studies found no difference for MI, CVD, stroke across groups for SU, DPP4i, or SGLT2i. DPP4i combination was superior, with .. Read More»