Amishi
Department of Applied Physics, Delhi Technological University Bawana Road Delhi, India
Publications
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Review Article
Age-Dependent Nonlinear Protein Aggregation: A Mathematical Model of Gut-Brain Axis Mediated Neurodegeneration
Author(s): Amishi and Himadri B. Bohidar*
Structural changes caused by misfolding, aggregation and clumping of proteins can manifest in serious pathological conditions. These also have a significant bearing on the biological activity of intrinsically disordered proteins (IDPs). Developing a general understanding of the neurodegenerative diseases by moving beyond the isolated age-based paradigms is one of the challenges of molecular biophysics. Herein, we propose a simple dynamic system level model that incorporates hormonal control, genetic predisposition, immune decline and the gut-brain axis as well as their interactions, to show that aggregation accelerates through critical tipping points rather than progressing steadily over time. Most strikingly, the model identifies a universal convergence around midlife, near the age of 47 years, when gender- specific protections fade and disease risk equalizes, and reveals gut dysbios.. Read More»