Tumor Tissue Often Depends on the Microenvironment in which it is Located

Abstract

Sinisa Franjic

The tumor microenvironment is the environment around the tumor, including the surrounding blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix. The tumor and the surrounding microenvironment are closely connected and in constant interaction. Tumors can influence the microenvironment by releasing extracellular signals, stimulating tumor angiogenesis and inducing peripheral immune tolerance, while immune cells can influence the growth and development of the microenvironment of cancerous cells.

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