Comparison of the distribution pattern of metastatic bone disease and Skeletal related events between breast and prostate cancer: A retrospective study in Khartoum Oncology Hospital 2020

Abstract

Mosab Ahmed Abker Adam, Alaa Othman Awadalkareim Gasmalla, Noura Mohamed Hassan Mohamed and Wagas Abbas Mohamed Ahmed Mansour

Background: Bone metastasis (BM) and its consequence skeletal-related events (SREs) are the most common cause of cancer pain and disability. In this study, we compare the distribution pattern of BM and SREs in breast cancer (BC) and prostate cancer (PC).
Materials and Method: A Retrospective study in Khartoum oncology hospital of the medical record from 29 September 2019 to March 2020. Demographic and clinical information extracted from the medical records of eligible patients in the last 5 years 2015-2019 included age, sex, social habits, duration of breast and prostate cancer, duration of treatment, site of BM, and SREs if present. Statistical analyses were performed using SPSS, Version 22.0. (IBM, USA).
Results: Out of 3216 patients, medical records 71.8% diagnosed with BC and 28.2% diagnosed with PC.5.6% had to BM the ratio between the breast and prostate is 1:4, Both cancers commonly metastasize to Spinal and pelvic bones. In comparison between BC and PC, the common site for BM according to the affected segment is lumber 48.8%, thoracic 32.9%, and pelvic 32.9% in BC. While in the PC: 56.9%, 50.5%, and 42.2% for lumbar, pelvic, and thoracic vertebrae respectively. SREs occur in 45.7% and 63.3% of BC and PC patients respectively.
Conclusion: Based on high incidence BM in the BC and PC, screening for BM as soon as cancer diagnosed should be done promptly. Skeletal complications signs should always be considered as a matter of priority, as it has an impact on patient quality of life.

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