A Phase Ii Randomized Control Study to Assess The Efficacy of Curcumin and Honey in Cough on Patients with Lung Cancer at A Tertiary Cancer Center, Hbni, Mumbai

Abstract

Prathepa Jagdiish, Snehal Shinde, Vijay Patil, Vanita Noronha, Nandini Menon, KumarPrabash, Vikram Ghota and Akash Pawar

Introduction: Lung cancer is the most important cancer in men and the 2nd most common cancer in women in India with the largest fatality .Squamous cell carcinoma and small cell undifferentiated lung cancer are more likely to be associated with cough. Symptoms include dyspnea , persistent cough and haemoptysis. In these scenario curcumin represents a promising and effective anticancer drug to be used alone or in combination with other drugs to treat cough . It affects different signalling pathways and molecular targets involved in the development of several cancers. Its biological activities such as antioxidant, anti-inflammatory, antimicrobial, antiviral, among which its anticancer potential has been the most described. Honey is rich in flavonoids. Flavonoids has its anticancer properties. The mechanisms suggested are rather diverse such as various signalling pathways , including stimulation of TNF-alpha release , inhibition of cell proliferation, induction of apoptosis and cell cycle arrest as well as inhibition of lipoprotein oxidation

Objectives: Primary objective was to assess the efficacy of curcumin and honey on cough in patients with lung cancer at a tertiary cancer centre . Secondary objectives were to assess incidence & degree of cough, to find out the association between clinical data and efficacy of curcumin and honey

Methodology: Quantitative approach with randomized controlled trial (open labelled) design. Targeted Population Lung cancer patients with cough. Total 52 patients participated in the study. Control arm participants received standardized treatment with no intervention. Participants from experimental arm had curcumin 500mg with 5 ml of honey mixed together for three time a day orally for 21 days .Cough visual analogue scale was used . Data were analysed using descriptive and inferential statistics using SPSS version 25.

Results: Mann Whitney U test was carried to check difference between control and intervention group on day 0, day 10 and day 22 . It was found that for CVAS p value was < 0.05, indicating a statistically significant difference in the experimental arm.

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