Advances in Hematology and Oncology Research(AHOR)

Department of Laboratory Medicine, The First Afiliated Hospital of USTC, China

Publications

• Research Article   
  7-Dehydrocholesterol Reductase is a Promising Prognostic and Immune Biomarker in Pan-Cancer
  Author(s): Xianghua Wu, Weiwei Zheng, Li Wang, Xuzhao Zhang, Dan Lin* and Zhaoxing Wu*
  
  Background: 7-Dehydrocholesterol Reductase (DHCR7) is a key enzyme involving the final step of cholesterol synthesis path- way. Abnormalities in the DHCR7 gene can lead to a variety of diseases, such as Smith-Lemli-Opitz syndrome. However, the relationship between DHCR7 and oncogenesis remain unclear. Methods: We used several bioinformatic databases which the original data from the TCGA and GEO database. Briefly, the gene of DHCR7 expression were explored by the Oncomine, TIMER and GEPIA databases. The effect of DHCR7 on prognosis was analyzed via Kaplan-Meier plotter and GEPIA database. The TISIDB database was used to determine the relationship between DHCR7 expression and pan-cancer stages and the DHCR7 expression in different immune and molecular subtypes of human cancers. The correlations between DHCR7 expression and Immune Checkpoints (.. Read More»
  

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