Wei Chen
Cardiology Department, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 20004, China
Publications
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Research Article
The Efficacy and Safety of the Off Label Dose of Direct Oral Anti Coagulants Treatment in Patients with Atrial Fibrillation in China
Author(s): Peng Zhou, Meng Wang, Rongchen Liu, Yangjie Yu, Wei Chen, Yunzhi Ma, Hengyang Wang, Maieryemu Waresi, Vladimir Melnikov, Xinping Luo and Jian Li*
Background: Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Anti-coagulation therapy, especially direct oral anti-coagulants (DOACs) is an indispensable therapy for AF. Considering the increased risks of bleeding, the off-label dose of DOACs has been applied in East Asia. However, the efficacy and safety of off-label dose of DOACs is controversial. Here, we investigate its efficacy and safety in AF patients in China. Methods: This is a retrospective cohort study. Patients diagnosed with AF between January 2015 and December 2015 were recruited. Participants were divided into three groups according to DOACs dose: standard dose of anti-coagulation (SAG) group, off-label dose of DOACs (OFL) group and non-anti-coagulation (NCG) group. Primary endpoint event was all-cause mortality. Secondary endpoint events included t.. Read More»