Archives of Clinical and Medical Microbiology(ACMMJ)

Department of Pathology & Laboratory Medicine, Arnot Ogden Medical Center, Elmira, USA

Publications

• Research Article   
  Challenging Standard Protocols: A New Perspective on MMR Deficiency from a Longitudinal Regional Study
  Author(s): Eric Y Zhang, Min Yan, Victoria LS Owens and Yan Xia*
  
  The role of DNA mismatch repair (MMR) tumor testing in colon and endometrial carcinomas is well-established. However, the universal application of this testing faces challenges. These challenges are due to limited data on its efficacy in diverse populations. This retrospective study was conducted at a community hospital in Northern Indiana, USA. It examined MMR immunohistochemistry (IHC) results across 549 cases. Our analysis found that 469 cases had intact MMR expression. Meanwhile, 80 cases demonstrated MMR deficiency. This translates to MMR deficiency rates of 10% in colon cancers and 22% in uterine carcinomas. Notably, only 16 patients (2.9%) were categorized as having high microsatellite instability (MSI-H). This rate is significantly lower than the 3-5-fold higher incidences reported in other Midwestern populations, including Ohio. These findings suggest that the benefits of uni.. Read More»
  

  Abstract HTML PDF