Journal of Clinical Review & Case Reports(JCRC)

Department of Anesthesiology, Keio University School of Medicine, Japan

Publications

• Review Article   
  Acute lung injury after pulmonary resection surgery for lung cancer and anesthetic management
  Author(s): Takeshi Suzuki*, Kenta Wakaizumi, Jungo Kato, Takashige Yamada and Hiroshi Morisaki
  
  Although the outcome of patients undergoing pulmonary resection surgeries for lung cancer has improved, postoperative acute lung injury (ALI) remains the leading cause of death. High oxygen concentration, high peak airway pressure, and hyper-perfusion due to hypoxic pulmonary vasoconstriction play a major role in the development of ALI in the ventilated dependent lung during one-lung ventilation. In the collapsed non-dependent lung, mechanical stress induced by re-expansion, ischemia-reperfusion injury, and direct surgical manipulation are associated with the onset of ALI. These contributing factors to ALI elicit local inflammatory responses, resulting in pulmonary edema that resembles acute respiratory distress syndrome histologically. Some preventive strategies to reduce ALI are recommended during mechanical ventilation, OLV support in particular. A lung protective strategy, includi.. Read More»
  

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