Shouhartha Choudhury
HGK School of Life Sciences, Department of Biotechnology, Life Science and Bioinformatics, Assam University, India
Publications
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Research Article
In-Silico Analysis of Heart and Neural Crest Derivatives (HAND) Subclass Basic Helix-Loop-Helix (bHLH) Transcription Factor in Cardiogenesis
Author(s): Shouhartha Choudhury*
Background: The HANDs are muscle-specific bHLH TFs crucial for proper cardiac and extra-embryonic development. The eHAND and dHAND functioned in developing ventricular chambers (right and left ventricle), aortic arch arteries, cardiac neural crest, endocardium and epicardium. The down-regulated response of the eHAND and dHAND genes reflects permissiveness. A recent report suggested that cardiac hypertrophy intimate eHAND corresponds to cardiomyopathy and dHAND in the atrium. Those reports supported the cardiac muscles may re-initiate a fetal gene result and initiate physiological changes, which allow the heart to recompense. Objective: In this study, the objective is an investigation of the HAND subclass bHLH transcription factors in mammals. I like to classify the bHLH TFs and discuss the genetic evidence of both eHAND and dHAND genes in ca.. Read More»