Sheila Zimmermann Kibrit
Neurology, Clínica ARZ, Campinas, São Paulo, Brazil
Publications
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Case Report
Cortical Ribboning and Periodic EEG Discharges in Probable Sporadic Creutzfeldt-Jakob Disease
Author(s): Raphael Zimmermann*, Sheila Zimmermann Kibrit and Allan Zimmermann
Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive and fatal prion disease characterized by cognitive decline and variable neurological manifestations. Case Presentation: We report a 62-year-old woman who developed progressive memory impairment followed by severe neurological deterioration, diffuse myoclonus, and pyramidal and extrapyramidal signs. Brain magnetic resonance imaging (MRI) demonstrated diffuse bilateral cortical signal abnormalities with restricted diffusion and basal ganglia involvement. Electroencephalography (EEG) subsequently revealed generalized periodic sharp-wave complexes. Prion- specific cerebrospinal fluid (CSF) testing was unavailable. Conclusion: The combination of rapidly progressive cognitive impairment, characteristic neurological manifestations, MRI abnormal.. Read More»