Toxicology and Applied Pharmacology Insights(TAPI)

Depertment of Genetic Engineering and Biotechnology, Faculty of Earth and Ocean Science, Bangabandhu, Bangladesh

Publications

• Research Article   
  Polycystic Ovary Syndrome (PCOS) Inhibitory Drug Screening from Selective Inositols
  Author(s): Sheikh Shohag*, Shomaya Akhter, Saraban Tahura Antora, Kazi Ajija Nawer and Md. Abdul Alim
  
  Polycystic ovary syndrome (PCOS) is a heterogeneous ailment characterized by a combination of symptoms, including signs of androgen excess (hirsutism and/or hyperandrogenemia), ovarian dysfunction-oligo-ovulation and/or polycystic ovarian morphology (PCOM)), reproductive abnormalities, obesity, menstrual irregularity, type 2 diabetes (T2DM), hypertension, dyslipidemia, and depression. PubChem, enriched with 110 million chemicals, yielded 6327 inositol derivatives. Lipinski rule of five (MW up to 500 g/mol, H-bond donors 1–5, H-bond acceptors up to 10) criteria has been used for filtration of 582 compounds initial stage. Using escalating molecular weight, 101 molecules were selected from 582, to control this and rogen. To explore the possibility of androgen inhibition, various computational approaches, such as PASSprediction,protein-ligand interactions through molecular docking, .. Read More»
  

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