Shazaf Masood Sidhu
Resident Oncology – Fauji Foundation Hospital Rawalpindi, Pakistan
Publications
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Research Article
A Storm Within Remission: Multisystem Complications of All-Trans Retinoic Acid-Arsenic Trioxide Therapy in Acute Promyelocytic Leukemia
Author(s): Shazaf Masood Sidhu, Hafiz Muhammad Hamza*, Osman Wafai and Rida Maria
Background: Acute promyelocytic leukemia (APML) is a hematologic emergency with high curative potential when treated with all-trans ret- inoic acid (ATRA) and arsenic trioxide (ATO). However, early-phase induction therapy may be complicated by serious adverse events requiring rapid recognition and management. Case Presentation: We report the case of a 22 years old woman with newly diagnosed APML who developed multiple life-threatening complica- tions during induction therapy with ATRA and ATO. These included significant QT interval prolongation, severe electrolyte disturbances, focal seizures, pseudo-ischemic chest pain likely due to coronary vasospasm, and dural venous sinus thrombosis (DVST). Temporary discontinuation of therapy, aggressive supportive care, and coordinated multidisciplinary management enabled full recovery and re.. Read More»