Archivos de Ciencia e Investigación(ADCI)
ISSN: 3068-014X | DOI: 10.33140/ADCI
Shabnam Akhter
Associate Professor, Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Publications
-
Research Article
BRAF V600E Expression in Papillary Thyroid Carcinoma and its Association with Histological Prognostic Factors
Author(s): Fahmida Hasan Chowdhury, Sayedatus Saba*, Shabnam Akhter, Mohammad Mosiur Rahman, Eshana Paul, Md. Anik Biswas and Amena Begum
Background: Thyroid cancer is the most common endocrine tumor, accounting for 90% of all endocrine malignancies. Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. Despite its good prognosis, a small number of PTC cases develop lymph node metastasis, extrathyroidal extension, distant metastasis, or recurrent disease. The B-type RAF V600E (BRAF V600E) mutation is the most commonly observed genetic abnormality in PTC and PTC-derived anaplastic carcinoma. This study was done to determine the association between BRAF V600E expression in PTC and tumor size, multifocality, extrathyroidal extension, and chronic lymphocytic thyroiditis. Method: This was a cross-sectional study conducted with 50 cases of papillary thyroid cancer at the Department of Pathology, BSMMU, Dhaka, Bangladesh from March 2022 to February 2024. Tumor size, tu.. Read More»