International Journal of Diabetes & Metabolic Disorders(IJDMD)

The Karachi Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, Karac, Pakistan

Publications

• Research Article   
  Predominance of Catalase Gene Mutations in Type 2 Diabetes Mellitus High-Risk Population
  Author(s): Syeda Nuzhat Nawab*, Sanober Kafeel, Nazia Hassan, Afsheen Arif, Zehra Hashim and Ashar Fawwad
  
  Objective: To determine the-role of CAT -21-A/T (rs7943316) and -262 C/T (rs1001179) genetic/variants/in the susceptibility of type 2 diabetes mellitus (T2DM). The study also explored the likelihood of clinical and anthropometric-associated variations in T2DM. Methods: This case-control study comprised of total n=400 subjects categorized into two/groups: T2DM (n=200) and controls (n=200). Genotyping of variants/was-carried-out-by allele-specific (AS) and RFLP-PCR/based/strategies. Results: Distribution of genotypes revealed significant differences in both variants of CAT gene promotor. In CAT -21 A/T variant, the frequency of the mutant T/T genotype was higher in the T2DM group (56.0%) as controls (48.5%). While, in CAT -262 C/T variant, the frequency of heterozygous genotype C/T was significantly higher in disease.. Read More»
  

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