Insights of Herbal Medicine(IHM)

Department of Pharmacology, MCOPS, Manipal, India

Publications

• Research Article   
  Assessment of Basella Alba on Chemical Induced Hepatocellular Carcinoma in Rats
  Author(s): Gaddam Dayanand Reddy*, Ramaswamy Karthik, Sanjeev Kumar Ojha, Chandana Venkateswara Rao, Mazhuvancherry Unnikrishnan and Palpu Pushpangadan
  
  Chemical hepatotoxins including diethylnitrosamine (NDEA) and carbon tetrachloride (CCl4) frequently induce hepatocellular carcinoma (HCC), which is a leading cause of cancer-related deaths globally. Conventional therapy is still limited due to toxicity and poor prognosis, generating renewed interest in natural products as safer alternatives. Basella alba (B. alba) an edible leafy vegetable that has long been used in folk medicine, includes flavonoids, phenolics, carotenoids, and saponins, all of which have strong antioxidant properties. B. alba extract was administered to rats with NDEA + CCl4-induced HCC for 16 weeks. Biochemical, oxidative stress, and histological markers were assessed. The extract effectively restored blood liver function indices, reduced lipid peroxidation, increased antioxidant enzyme activity, and improved hepatic architecture by lowering necrosis and fibrosis... Read More»
  

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