Advances in Bioengineering and Biomedical Science Research(ABBSR)

Maternal and Child Health Hospital Affiliated to Nanchang University, Nanchang, Jiangxt, China

Publications

• Research Article   
  Multiple Datasets Revealed T Cell Pathway Related Genes Associated with Better Prognosis and Chemotherapy in Breast Cancer
  Author(s): Ping Chen*, Shuhui Lai*, Junping Deng, Sixuan Guo, Yangjuan Huang, Jian Li, Xiaowen Fang and Yaping Xie
  
  Breast cancer (BC) is the most frequent cancer diagnosed in women, and the second foremost source of cancer-related death. Despite conventional treatment, patients experience metastasis and poor survival. This study aimed to systematically validate the data of previous studies on BC to fill the gaps in large-scale meta-analyses and evaluate pivotal genes. We conducted meta-analysis on target genes chosen from the Gene Expression Omnibus (GEO) database to classify the differently expressed genes (DEGs). Then pathway enrichment study of the Kyoto Encyclopedia of Genes and Genomics (KEGG) and proteinproteins interaction (PPI) were performed to investigate the biological pathway leading to DEGs. Survival analysis and logistic regression of the receiver operating characteristics (ROC) were used to evaluate the ability of core gene expression to predict treatment efficacy. The KEGG pathway .. Read More»
  

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