Toxicology and Applied Pharmacology Insights(TAPI)
ISSN: 2641-0451 | DOI: 10.33140/TAPI
PetranovskaAP
Chuiko Institute of Surface Chemistry, NAS of Ukraine, Kyiv, Ukraine
Publications
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Research Article
Pharmacokinetics and Biological Effects of Ferromagnetic Nanocomposite in Rats with Sensitive and Ddp-Resistant Guerins Carcinoma
Author(s): ChekhunVF*, LukianovaN Yu, TodorIM, StorchaiDM, BorikunTV, NaleskinaLA, Kusiak АP, PetranovskaAP and HorbykPP
Aim: To study nanocomposite-based conjugate of ferromagnet and cisplatin pharmacokinetic parameters and its therapeutic pathomorphosis in rats with sensitive and DDP-resistant Guerin’s carcinoma. Material and Methods: The female Wistar rats with sensitive and DDP-resistant Guerin’s carcinoma received a nanocomposite-based conjugate of a ferromagnet and DDPonce at dose 3.5mg of DDP/kg intraperitoneally. All animals were anesthetized and samples of blood, tumour, liver and kidneys were collectedat 0.25, 0.5, 1, 3, 6 and 24h after the injection. Deposition of iron and platinum were measured using atomic absorption spectroscopy, AUC was calculated by trapezoidal method. Results: In both sensitive and resistant strains of Guerin’scarcinonma, maximum concentriation of Pt in tumor tissue and blood serum .. Read More»