Advancements in Journal of Urology and Nephrology(AJUN)
ISSN: 2689-8616 | DOI: 10.33140/AJUN
Impact Factor: 1.0
Peng Xia
Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430062 Hubei, People’s Republic of, China
Publications
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Research Article
Methylprednisolone Protects Severe Acute Pancreatitis And Pancreatitis-Associated Acute Lung Injury in Mice By Inhibiting NLRP3 Inflammasome Through NF-?B
Author(s): Chao He, Chuan-jiang Liu, Qiang Fu, Pan Liu, Peng Xia, Xu Zhang, Rui Chen, Zhen-sheng Zhai, Yu-zhu Wang, Tao Qin, Wenjing Zhou and Hong-wei Zhang*
In serve acute pancreatitis (SAP), the rapid production and releasing of inflammatory cytokines can cause local and systemic excessive inflammation, especially pancreatitis-associated acute lung injury (P-ALI). Methylprednisolone (MP) is a synthetic corticosteroid with potent anti-inflammatory and antioxidant properties used as therapy for a variety of diseases. In this study, we found MP, used in the early phase of SAP, decreased the levels of IL-1β and TNF-α in serum and peritoneal lavage fluids (PLF), reduced the level of serum amylase and the expression of MPO in lung tissue, attenuated the pathological injury of the pancreas and lungs in a dosedependent manner. The expression of NLRP3 and IL-1β in pancreas and lungs was down regulated significantly depending on the MP concentration. In vitro, MP reduced the levels of IL-1β and TNF-α by down regulating t.. Read More»