Journal of Future Medicine and Healthcare Innovation(JFMHI)
ISSN: 3065-7628 | DOI: 10.33140/JFMHI
Pablo Alvarez Aguilar(MD)
Universidad de Costa Rica, Costa Rica. ORCID: 0000-0002-3664-169x, Costa Rica
Publications
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Research Article
Biomarker- Or Phenotype-Guided Sedation in The Intensive Care Unit: A Systematic Review and Meta-Analysis of Patient-Centered Outcomes
Author(s): Antonio Andrea Camastra (MD)*, Rodrigo Ormanes Massoud(MS), Pablo Alvarez Aguilar(MD), Krithika Sriram(MD), Roland Amoah(MBBS, MRes), Rajarshi Bhadra(MD, FACP), Mario Diego Teles Correia (MD) and Shubhangi Humbre (DNB, IFCCM, EDIC)
Introduction: Current practices of sedation in intensive care units (ICUs) are inconsistent, often leading to over- or under-sedation, which are associated with adverse outcomes. Personalized sedation seeks to optimize regimens by incorporating individual characteristics, including pharmacogenomics, electroencephalogram (EEG) patterns, and disease phenotypes. This systematic review and meta-analysis summarizes recent evidence on phenotype- and biomarker- guided sedation in the ICU. Methods: Eligible studies included randomized controlled trials (RCTs) and observational studies evaluating biomarker- or phenotype-guided sedation with standard care in adult ICU patients. Searches were conducted in PubMed/MEDLINE, Embase, Cochrane CENTRAL, and ClinicalTrials.gov through May 1, 2025. Mean differences (MDs), standardized mean differences (MDs) or .. Read More»