Hypertension: Open Access(HOA)

Department of Cardiology, Faculty of Medicine, Mugla S?tk? Kocman University, Mugla, Turkey

Publications

• Review Article   
  Structural and Functional Cardiac Remodeling in Hypertension: Pathophysiology and Clinical Implications
  Author(s): Yusuf Solak, Macit Kalcık*, Abdullah Sarihan, Oguzhan Celik, Mehmet Mustafa Yilmaz, Osman Karaarslan, Mucahit Yetim, Muhammet Cihat Celik, Lutfu Bekar and Yusuf Karavelioglu
  
  Hypertension induces a broad spectrum of structural and functional alterations in the myocardium collectively defined as cardiac remodeling. Initially, these changes represent adaptive responses to sustained pressure overload aimed at preserving cardiac output through increased wall thickness and normalization of wall stress. However, persistent hemodynamic burden and neurohormonal activation lead to maladaptive remodeling characterized by left ventricular hypertrophy, interstitial fibrosis, microvascular dysfunction, and impaired diastolic relaxation. These structural and molecular alterations are closely linked to the development of heart failure with preserved ejection fraction, atrial fibrillation, and increased susceptibility to ischemia. Contemporary imaging modalities, including echocardiographic strain analysis and cardiac magnetic resonance, have improved the detection of sub.. Read More»
  

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