Advances in Hematology and Oncology Research(AHOR)
ISSN: 2692-5516 | DOI: 10.33140/AHOR
Impact Factor: 1.2
Nicole Mioto Medeiros
Internal Medicine Residency Program, Portuguese Beneficent Hospital of Santos, Santos, Sao Paulo, Brazil
Publications
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Research Article
Sickle Cell Anemia: Therapeutic Advances, Disease-Modifying Therapies, and Future Prospects
Author(s): Rosane Rezende de Souza Giuliani, Felipe Santos Teixeira Martiniano, Nicole Mioto Medeiros, Lorenzo Francesco Giuliani, Ana Laura Munerato Zoega Marotti, Maria Beatriz Mendonça Ventura, Filipe J. L. Garcia and Thiago Augusto Rochetti Bezerra*
Introduction: Sickle cell disease is the most prevalent inherited hemoglobinopathy worldwide, characterized by chronic hemolysis, systemic inflammation, and recurrent episodes of vaso-occlusion, which are responsible for high morbidity and mortality. In recent decades, therapeutic advances have expanded treatment options, including disease-modifying therapies, hematopoietic stem cell transplantation, and gene therapy. Objective: To analyze the scientific evidence regarding therapeutic advances, disease-modifying therapies, and future prospects for the treatment of sickle cell anemia. Methods: A systematic review conducted in accordance with PRISMA guidelines, using the databases PubMed, Scopus, Web of Science, Embase, the Cochrane Library, and ScienceDirect. Studies published between 2016 and 2026 were included, co.. Read More»