Journal of Veterinary Health Science(JVHS)
ISSN: 2831-3887 | DOI: 10.33140/JVHS
Impact Factor: 0.762
Mohammad Saleh Ranaiy (MSc)
Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
Publications
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Research Article
Degeneration of Granule Neurons In The Dentate Gyrus (Dg) Area In The Hippocampus In Male Rats Under The Influence of Simvastatin
Author(s): Mohammad Saleh Ranaiy (MSc)*, Farah Farokhi (Ph.D.) and Farrin Babaei-Balderlou (Ph.D.)
Background: Simvastatin is a lipophilic statin used to prevent and treat hypercholesterolemia. This study aimed to evaluate the effect of simvastatin on the appearance specifications of the DG region Hippocampus. Method: For the experiment, 36 male Wistar rats with an average weight of 300-250 g were divided into six groups (each group comprised six heads). Groups: 1): Control group, 2): Vitamin D dose 5 µg/kg, 3): Simvastatin group dose 1 mg/kg, 4): Simvastatin group dose 10 mg/kg, 5): Simvastatin group dose 1 mg/kg + vitamin D dose 5 µg/kg, 6): Simvastatin group dose 10 mg/kg + vitamin D dose 5 µg/kg. The duration of drug use was 28 days. At the end of the drug administration period, the animals were slaughtered, and then the brain tissue of the animals was extracted to prepare microscopic sections. Results:.. Read More»