Mohamed Zain
Department of Histology, Armed Forces College of Medicine (AFCM), Egypt
Publications
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Mini Review Article
STEM CELL therapy and Diabetes
Author(s): Sahar MM Omar, Mahmoud Bastawesy, Hassan Fareed, Abde lhameed Ghazy, Mohamed Elkazaz, Mohamed Zain, Hossam Algamal and Mustafa Abogasser
Diabetes is the most prevailing disease with progressive incidence worldwide. To the moment, there is no permanent treatment available for diabetes. Hopefully, stem cell-derived islets may likely be the future therapy. However, the field has limited capability to generate beta-like cells with both phenotypic maturation and functional glucose stimulated insulin secretion that is like primary human islets. Several promising approaches to cure diabetes are to use Mesenchymal stem cells (MSCs) from perinatal tissues or human pluripotent stem cells (hPSCs), including embryonic stem cells (hESCs) and human induced PCSs (hiPSCs). It is also crucial to establish a reliable method of delivering the cells to patients ensuring rapid in-vivo engraftment and function. Overcoming these barriers to beta cell differentiation and transplantation will be key to bring this dream to the clinic. Much rese.. Read More»