Journal of Veterinary Health Science(JVHS)

College of Veterinary Medicine, Haramaya University Po Box 138, Haramaya, Ethiopia

Publications

• Review Article   
  Mycobacterium Avium Sub Species Paratuberculosis: Virulence Mechanism and Recent Vaccine Developments: A Review
  Author(s): Misgana Bekele Daba*
  
  Mycobacterium avium subsp. Paratuberculosis (MAP) causes chronic inflammation of the intestine known as Johne’s disease in domestic and wild ruminants. This bacterium has also been linked to Crohn's disease, an inflammatory bowel illness in humans. Young animals are thought to be the most vulnerable to infection via oral uptake of the bacterium from a polluted environment. Following oral uptake, the bacterium can move through the intestinal wall to the basolateral side of the gut via the M cells. Following their discharge into the extracellular fluid of the lami- na propria, these bacteria are picked up by macrophages, which ordinarily digest bacteria by enzymatic activities. Mycobacterium paratuberculosis, on the other hand, is specialized in preventing phagosome-lysosome fusion, al- lowing it to survive inside macrophages. Furthermore, they send anti-apoptotic signals, all.. Read More»
  

  Abstract HTML PDF