Advances in Bioengineering and Biomedical Science Research(ABBSR)

Professor, Department of Pharmacology, Bharat Institute of Technology, Mangalpally, Jawaharlal Nehru, India

Publications

• Research Article   
  Hepatoprotective Activity of Amomum Subulatum (Roxb.) Seeds against ParacetamolInduced Liver Damage in Rats
  Author(s): Mihir Y Parmar*, Purvi A Shah, Vaishali T Thakkar and Tejal R Gandhi
  
  Hepatoprotective activity of methanolic extract of Amomum subulatum seeds (MEAS) was evaluated against paracetamol (3 g/kg, p.o. for 3 days) induced liver damage in rats. The degree of protection was measured using serum biomarkers like Alanine and Aspartate aminotransferase, alkaline phosphatase, total and direct bilirubin, lactate dehydrogenase, gamma glutamyl transferase and total protein; oxidative stress parameters such as malondialdehyde, glutathione, super oxide dismutase and catalase along with histopathology. Significant higher levels of above serum biomarkers, whereas lower level of total protein in paracetamol control as compared to normal control was observed. Treatments with MEAS and silymarin caused significant reversal in above biomarkers which was altered by paracetamol. Similarly, significant increase in MDA while decrease in GSH level, SOD and CAT activities in parac.. Read More»
  

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