Journal of Clinical, Medical, and Diagnostic Research(JCMDR)

Department of Biological Sciences, Hanshan Normal University, China

Publications

• Research Article   
  Exogenous H2S Regulates CSE Expression in HUVECs under Hypoxic Conditions
  Author(s): Maoxian Wang*
  
  Hydrogen sulfide (H2 S) is a gaseous signaling molecule synthesized in the body by three enzymes: cystathionine-beta- synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST). CSE plays a crucial role in the production H2 S in the cardiovascular system. The primary objective of this study was to investigate the effects of exogenous H2 S on CSE expression in vascular endothelial cells under hypoxic conditions. Using luciferase assays, quantitative RT-qPCR, and western blotting, we conducted a comprehensive analysis of the regulatory effects of 100 μM H2 S on CSE transcription and expression in human umbilical vein endothelial cells (HUVECs) subjected to hypoxia. This study specifically examined the impact of exogenous H2 S on CSE promoter activity in HUVECs. Notably, compared to 0 μM H2 S, exposure to 100 μM H2 S resulted in a significa.. Read More»
  

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