International Journal of Women's Health Care(IJWHC)

Professor of Physiology, Titu Maiorescu University, Bucharest, Romania

Publications

• Review Article   
  Role of P-53 Gene in Preventing Breast Cancer
  Author(s): Aurelian Udristioiu* and Manole Cojocaru
  
  Breast cancer affects more than one million patients annually in the world and is a leading cause of mortality. Histological type, grade, tumor size, lymph node involvement, and estrogen receptor and HER-2 receptor status, all influence prognosis and the probability of response to systemic therapies. P53 gene is mutated in about 30% of breast cancers/.The possible links between alterations of p53 and clinical or pathological features of breast tumors have been widely investigated. The first study to examine gene-expression patterns of breast cancer suggested that at least four major molecular classes of breast cancer exist: luminal-like, basal-like, normal like, and HER-2 positive. Basal-like breast cancer account for 15% of breast cancers and are often described as triple negative breast cancers (TNBCs). In fact, TNBCs, defined by lack of expression of estrogen receptor, pr.. Read More»
  

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