Archivos de Ciencia e Investigación(ADCI)
ISSN: 3068-014X | DOI: 10.33140/ADCI
Mandeep Singh
MBBS Student, Independent Researcher, Shaheed Hasan Khan Mewati, Government Medical College Nalhar, India
Publications
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Research Article
Selective Thymic Glucocorticoid Receptor Modulation by Giving Pro-Drug Thymosine α-1 Immuno-Modulator in Chronic Level of Glucocorticoids Exposure Thus Preventing Autoreactive T Cells Production and Establishing Central Tolerance
Author(s): Sourav Singla*, Kartikey Sringari, Yogesh Khaleri, Prisha Sharma, Mandeep Singh and Jasimar Kaur
Background: We developing a pro-drug to protect the thymus against the atrophy caused by chronic glucocorticoids level in body and suppress production of auto reactive T cell from thymus without inhibiting normal T cell proliferation and thus prevent autoimmune disorder and delay various stages of autoimmunity. Conceptual Innovation and Scientific Rationale: Re-engineering thymosin α-1 as a pro drug that protects T cell from chronic glucocorticoid levels. Thymosin α-1 potentiates T cell mediated immune response via differentiation and maturation of T cell progenitor cells3. Vamorolone (VBP 15) shows potent inhibition of pro inflammatory NF-kB(Nuclear Factor kappa light chain enhancer of activated B cells) pathways via high-affinity binding to the glucocorticoid receptor4. Proposed Concept and Methodology.. Read More»