Longkuan Li
Third Affiliated Hospital of Guizhou Medical University, Duyun, Guizhou, China
Publications
-
Research Article
Screening and Identification of tsRNA Expression Profiles in Adriamycin-Resistant Acute Myeloid Leukemia Cells
Author(s): Fuxue Meng*, Longkuan Li, Wei Jia, Xin Yang and Zhiqing Xie*
Background: Refractory and relapse, caused by resistance to chemotherapy, which is the primary treatment for acute myeloid leukemia (AML), are the major hindrance in the cure of AML patients. Currently, tRNA-derived small RNAs (tsRNAs) are considered to be novel and potential non-coding RNAs that are involved in various cellular processes and play an important role in cancer progression. However, the expression of tsRNAs in AML resistant cells remain unclear. Methods: In this study, the expression profiles of tsRNAs in AML resistant cells were determined by arraystar small RNA microarray analysis, further detailed analysis and expression verification were carried out. Results: Our study reveals the distribution of tsRNA in AML resistant cells and confirms that expression of tsRNAs including up- regul.. Read More»