Jawairia Kiran
Centre of Biotechnology and Microbiology, University of Peshawar, Pakistan
Publications
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Research Article
Comparative Analysis of Orthologous Mast Cell Chymases Active Sites Using Bioinformatics Tools
Author(s): Jawairia Kiran* and Sadaf Chiragh
Mast cells, neutrophils, basophils, natural killer cells, and cytotoxic T cells are among the hematopoietic cell lines originating from immune cells. The importance of mammalian mast cells in innate immunity has piqued the scientific community's interest. cytoplasmic granules of mast cells. Histamine, proteoglycans, proteins, and cytokines are examples of compounds (mediators) that produce mast cell cytoplasmic granules. When external stimuli are received, these granules are released, causing degranulation. Mast cells generate a lot of proteases including chymase, tryptase, and type A carboxypeptidase, among other things. The structure of chymase cma1 was unknown in mice, but it shares 74 percent of its human sequence with chymase CMA1, which was used as a reference. The human CMA1 structure was used to establish and interpret the mouse cma1 structure. Significant residues from th.. Read More»