Journal of Clinical & Experimental Immunology(JCEI)

Formerly Bone & Joint Research Unit, Medical College Of The Royal London Hospital, United Kingdom

Publications

• Review Article   
  HLA-1-opathies and peptides
  Author(s): James R Archer*
  
  It is almost 50 years since it was realised that specific HLA molecules are associated with numerous chronic inflammatory diseases [1]. The HLA-1-opathies were subsequently defined as a subgroup of these, characterized genetically by three specific genes - a class I HLA which controls the particular disease, ERAP1, coding an endopeptidase trimming the peptides included in the class I heterotrimer and IL23R, coding part of the IL23 receptor, which affects the strength and nature of the inflammatory response [2]. Originally, the most obvious association was of the class I molecule HLA B27 with the arthritic disease ankylosing spondylitis (AS), which is now included in axial spondyloarthropathy (axSpa) [3,4]. As it was assumed that HLA molecules were involved in protection from infection, extensive efforts were made to identify microbial agents causing these diseases. Currently, however,.. Read More»
  

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